Email: h.philippou@leeds.ac.uk

Research profile and key clinical specialties

Professor Philippou has researched blood coagulation and thrombosis for over 25 years.

Within the last 8 years, her focus has turned towards using this knowledge and the most recent research to develop novel therapies and diagnostics to address unmet clinical needs of patient care in the fields of thrombosis and haemostasis.

Professor Philippou’s current activities include:

• a drug discovery programme developing an oral first-in class anticoagulant with no bleeding side-effects;
• an early stage drug discovery programme to develop an oral first-in class anti-platelet agent with minimal bleeding side-effects;
• characterisation of novel mechanisms related to thrombosis and haemostasis.

Two key publications

• Kearney KJ, Butler J, Posada OM, Wilson C, Heal S, Ali M, Hardy L, Ahnström J, Gailani D, Foster R, Hethershaw E, Longstaff C, Philippou H. Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2014810118.
• Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis. Duval C, Ali M, Chaudhry WW, Ridger VC, Ariëns RA, Philippou H. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):308-16.

Possible PhD projects

• Characterisation of novel targets to enhance stroke therapy
• Characterisation of novel mechanisms of thrombosis
• Preventing bleeding in trauma

More information

• View full research profile

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Keywords: coagulation, thrombosis, haemostasis, thrombin, fibrin, Murine Model, stroke, bleeding, Helen, Philippou, Leeds

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