Email: jacky.smith@manchester.ac.uk

Research profile and key clinical specialties

I run a multi-disciplinary research team based at Manchester University NHS Foundation Trust, whose focus is on understanding mechanisms underlying cough.

We have developed a commercialised device for objectively monitoring cough events, which we utilise in early phase clinical trials of novel therapies and experimental medicine studies.

Two key publications

• Rayid Abdulqawi, Rachel Dockry, Kimberly Holt, Gary Layton, Bruce G. McCarthy, Anthony P. Ford, Jaclyn A. Smith. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. Lancet. 2015 Mar 28;385(9974):1198-205
• Maria G.Belvisi, Mark A. Birrell, Saifudin Khalid, Michael A. Wortley, Rachel Dockry, Julie Coote, Kimberley Holt, Eric Dubuis, Angela Kelsall, Sarah A. Maher, Sara Bonvini, Ashley Woodcock, Jaclyn A. Smith. Neuro-phenotypes in Airway Diseases: insights from translational cough studies. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1364-72

Possible PhD projects

• Role of ATP in Initiating Airway Reflexes
• Neuro-immune Interactions in the Airways

More information

I run the NIHR Manchester Clinical Research facility at the University Hospital of South Manchester. View my full profile.

Keywords: Cough, Neuro-phenotypes, airway, NIHR, Jacky, Smith, Manchester

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