Email: pamela.shaw@sheffield.ac.uk

Research profile and key clinical specialties

Pamela Shaw is Professor of Neurology at the University of Sheffield. Her talents have transformed the approach to clinical neurosciences in Sheffield from an excellent but clinically orientated department to a centre providing academic leadership, excellent opportunities for trainees, and research productivity that is internationally competitive.

However, through systematic investment in basic neuroscience technologies coupled to the analyses of clinical neurology, Pamela has steadily illuminated mechanisms of cell death in the motor neurone diseases, characterized the molecular neuropathology of these conditions, and opened up the prospects for better treatments.

The range of molecular, genetic and clinical contributions she commands has attracted international recognition and the award of several prizes. Pamela’s commitment to the support of academic neurology is recognised by membership of the Neurosciences Sub-Panel of RAE 2001, past membership of the Wellcome Trust Neurosciences and Mental Health Panel, and Chairmanship of the Clinical Research and Academic Committee of the Association of British Neurologists, for whom she has produced a comprehensive and forward looking analysis of the clinical neurosciences.

Two key publications

• Sequestration of multiple RNA recognition motif proteins by C9ORF72 GGGGCC expanded repeats in amyotrophic laterals sclerosis. M J Walsh, J Cooper-Knock, A Higginbottom, JR Highley, J Bury, M Dickman, M Rattray, PR Heath, M Wyles, S Wharton, PG Ince, S Wilson, J Kirby, GM Hautbergue, PJ Shaw. Brain 137:2040-2051; 2014.
• Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis. G Nardo, R Iennaco, N Fusi, PR Heath, M Marino, MC Trolese, L Ferraiuolo, N Lawrence, PJ Shaw**, C Bendotti**. Equal contribution. Brain 136:3305-3332;2013 (EPub September 24). d.o.i: 10.193/brain/awt250; PMID:24065725.

Possible PhD projects

• Identification of translatable biomarkers of motor neuron injury and neuroprotection in experimental models of amyotrophic lateral sclerosis and the human disease.

More information

Supervised to completion 30 PhD students, including 11 clinical fellows

Keywords: Neurology, neurosciences, Neurologists mental health, motor neurone, molecular, genetic, Pamela, Shaw, Sheffield

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