Email: a.m.condliffe@sheffield.ac.uk

Research profile and key clinical specialties

Defects in innate and adaptive immunity lead to infection with a predilection for the respiratory tract, yet immune cell infiltration underpins a range of inflammatory and allergic respiratory diseases such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS) and asthma.

To clarify the role of dysregulated immunity in these diseases, I wish to address the following questions:

• How does immune cell function become deranged to promote disease pathogenesis rather than host defence?
• Can we identify cellular defects that predispose to recurrent respiratory infections?
• How can we use this knowledge to further diagnostic, prognostic and therapeutic interventions in diseases driven by aberrant immunity?

Two key publications

• Angulo-Herrera I, Vadas O, Garson F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, et al (joint senior author). An inherited PIK3CD mutation increases phosphoinositide 3-kinase delta activity and predisposes to recurrent respiratory infections and bronchiectasis. Science 2013; 342:866-71. Juss JK, House D, Amour A, Begg M, Herre J, Storisteanu DM, Hoenderdos K, Bradley G, Lennon M, Summers C, (joint senior author) ARDS Neutrophils Have a Distinct Phenotype and are Resistant to Phosphoinositide 3-kinase Inhibition. Am J Respir Crit Care Med. 2016 Apr 11. [Epub ahead of print] PMID 27064380.

Possible PhD projects

• Cognitive problems and autism spectrum disorder secondary to enhanced PI3- kinase signalling; new insights from the Activated PI3 Kinase Delta Syndrome.

More information

Currently supervise other students including a Clinical Research Training Fellow, students funded by charities, a departmental student and a Florey Global Strategic Alliance Student.

Keywords: Immunity, infection, allergic, respiratory, diseases, COPD, ARDS, asthma, bronchiectasis, infections, Alison, Condliffe, Sheffield

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